Lab-on-a-chip Capillary Electrophoresis


We are constructing a variety of microfluidic devices for labs on a chip . We use some of the same processes developed for the fabrication of ARROW waveguides. 
Electroosmotic Flow (EOF) pumps are shown below in Figure 1.



Figure 1 - SEM images of EOF pump features. (a) Cross-sectional view of a 5-?m EOF channel. (b) Cross-sectional view of a 50 ?m flow channel. (c) Top view of the pump channels interfaced with the flow channel.


Figure 2 - Thin-film sacrificially formed microdevices for CE analysis. (Top) SEM images of microchannels; scale bar is 20 ?m. (Bottom) Electropherogram of three FITC-labeled peptides separated at 830 V/cm in a planar thin-film microfluidic channel treated with UltraTrol Dynamic Precoat HR. Peaks are: (1) FLEEI, (2) Leu enkephalin, and(3) GGYR.

Figure 2 shows channels capable of electrophoretic separations. These structures require T-junctions and interfaces with macroscopic fluid reservoirs. So far, amino acids and peptides have been separated in these channels with results shown in Figure 2 for a peptide separation. Channels with different cross-sectional geometries were also created, including rectangular and arch shapes. This work was done in collaboration with Profs. Milton Lee and Adam Woolley in BYU's Chemistry Department 

Articles discussing our work are listed below:

BYU News Release

Deseret News Article

CNET News Article

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